(Dynamic Personalized Respiratory Medicine)
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease that has become the third leading cause of death in the world after heart disease and stroke.
Multiple biological pathways and mechanisms are known to be involved in COPD pathogenesis, in a complex process that involves the action of multiple cell types, mechanisms to damage both tissue and extra-cellular matrix, mechanisms that impair repair, acute responses followed by chronic responses, epigenetics modifications, and cross-talk with several other diseases. However, there are several reasons for which we still can’t develop reliable strategies to fight COPD, including: (a) The disease is a dynamic process, with different mechanisms involved at different stages, and (b) It is highly heterogeneous among patients.
This project follows a personalized and dynamic pathway analysis approach, that is, we are building a pipeline that uses state-of-the-art methods for functional interpretation of dynamic and heterogeneous data and apply them to COPD data.